Instructor: Prof Dr Habil Raluca-Ioana van Staden

Full day course: 31 August 2018

Target Audience:

This course is intended for chemists, materials scientists, biochemist, and engineers with an interest in applying bioanalysis in the determination of the quality of life, food, environment, and pharmaceutical products. Finding reliable tools like electrochemical and optical sensors for bioanalysis is in the trend. The attendee will develop a basic understanding of the tools and methods used in bioanalysis, and will be introduced to the new concepts on bioanalysis developed in the Division of Analytical Chemistry – Study group on Bioanalytics.

The topics to be covered include:

  • Principles of molecular recognition in bioanalysis;
  • Tools used in bioanalysis
  • Types of electrochemical sensors used in bioanalysis: from potentiometric membrane electrodes to amperometric sensors, stochastic sensors, biosensors, immunosensors, multimode sensors; general aspects,
  • Mechanism of molecular recognition of biomolecules,
  • Design of the electrochemical sensors, and methods of the characterization of the active surface of sensors,
  • Optical sensors and methods used for bioanalysis,
  • Genomics and proteomics for bioanalysis,
  • Separation methods for bioanalysis,
  • Validation of methods used for bioanalysis
  • Applications of bioanalysis in biomedical analysis, pharmaceutical analysis, environmental analysis and food analysis.

References:

  1. “Electrochemical Sensors in Bioanalysis”, R.I. Stefan, J.F. van Staden and H.Y. Aboul-Enein, Marcel Dekker Inc., New York, USA, 2001.
  2. Terminology of bioanalytical methods (IUPAC Recommendations 2018), Ján Labuda, Richard P. Bowater, Miroslav Fojta, Günter Gauglitz, Zdeněk Glatz, Ivan Hapala, Jan Havliš, Ferenc Kilar, Aniko Kilar, Lenka Malinovská, Heli M. M. Sirén, Petr Skládal, Federico Torta, Martin Valachovič, Michaela Wimmerová, Zbyněk Zdráhal, David Brynn Hibbert, Pure Appl. Chem. 2018; 90(7): 1121–1198

 

Raluca-Ioana van Staden is a Full Professor at University Politehnica of Bucharest and the Head of the Laboratory of Electrochemistry and PATLAB Bucharest in the National Institute of Research of Electrochemistry and Condensed Matter. She was an Associate Professor of Bioanalysis at the University of Pretoria (South Africa) and Assistant Professor at University of Bucharest. She is the head of the Study group Bioanalytics, of DAC. The author and co-author of more than 260 articles in journals especially in the fields of electrochemical sensors, bioanalysis (ion-selective membrane electrodes, enantioselective, potentiometric membrane electrodes, biosensors, immunosensors), process technology and flow systems (flow and sequential injection analysis), of three book: “Quality and reliability in analytical chemistry” (CRC Press), “Electrochemical Sensors in Bioanalysis” (Marcel Dekker, Inc) and “Laboratory Auditing for Quality and Regulatory Compliance” (Taylor and Francis) as well as of numerous chapters in books most of them related to sensors technology, she serves on the Editorial Boards of Preparative Biochemistry and Biotechnology (Marcel Dekker, Inc.), and Sensors and Transducers Journal. Lately, she developed new types of sensors (potentiometric enantioselective membrane electrodes, biosensors and immunosensors) for the analysis of chiral drugs and she also did the modeling of interaction between enantiomer and chiral selector; she is also the initiator of simultaneous detection of enantiomers using (bio)sensors/sequential injection analysis systems. She received numerous international prizes from societies such as South African Chemical Institute (Raikes Medal), IUPAC, World International Laboratory, and from innovation salons from Geneva, Warsaw, Moscow, Brussels. The most important prize – WIPO AWARD FOR THE BEST WOMEN INVENTOR was received in Geneva in 2010, at the 38th Salon of Innovation and New Products for a microsensor capable to diagnosed 4 types of cancer in less than 6 minutes. She was invited for lectures in Romania (Bucharest), Belgium (Antwerpen), Austria (Vienna), Israel (Jerusalem), South Africa (Pretoria), USA (New Orleans, Boston), Japan and Australia (Perth) and she has more than 300 presentations at international conferences and symposium in Europe, North and South America, Asia and Africa. A member of the American Chemical Society, International Society of Electrochemistry, The Electrochemical Society  and Romanian Society of Chemistry, as well as a Chair of the Bioanalysis Study Group in the Division of Analytical Chemistry of EUCHEMs, she received the B.Sc. degree (1992), the  Ph.D. degree (1997) in chemistry from the University of Bucharest, Romania, the habilitation in 2013, and the B.Sc. degree (1996) in piano and musical education and the M.Sc. degree (1997) in musical composition from the National University of Music, Bucharest, Romania.