Monday, September 2, 2019

 

 


Emeric Gueneau
Biacore Application Specialist, GE Healthcare

“To Affinity and Beyond : Biomolecular interaction analysis using Surface Plasmon Resonance”




Wesam AbuSaif
CAS Specialist

“Chemical Abstracts Service collective data to find the best analytical methods”

MethodsNow is one of the latest Chemical Abstracts Service product to solve an important problem that many analytical chemists are facing which is developing the best analytical method for their analyte. Chemical Abstracts Service scientists went back to all the analytical methods published after year 2000 and rewrite the analytical methods in a protocol form. I Will give some historical background about Chemical Abstracts Service and I will show some examples of how to find very good methods in few minutes.

Tuesday, September 3th, 2019

Vladimir Ioffe, Ph.D.
Associate Director, Scientific Expert, Analytical Development, Global R&D

In this seminar, specific problems related to gradient RP HPLC methods will be discussed, as well as the ways of solving them.
The first problem is the most common: the influence of dwell volume mismatch between different instruments, which results in difficulties in transfer of gradient methods. This problem is illustrated with typical examples of why some brilliant methods are hard to transfer and how to solve such issues in intra- and interlaboratory studies.
Various types of gradient equipment are presented and the simple method of dwell volume determination is explained.
The second problem is the gradient shape: how accurate is the mixer and what is the reason that in the gradient methods retention time drift may be different in the different segments of the chromatogram. Simple but efficient methods of testing of functioning of the mixers in the gradient chromatographic systems to ensure the proper gradient shape are explained.
The third problem is the gradient artifact peaks. This is the most complicated part of the problems associated with baseline issues.
The “components” of gradient baseline shape are analyzed, including their influence on analytical result. The main aim of this part is to learn how to diagnose gradient artifact peaks and how to get rid of them. The questions of quality of solvents and reagents, as well as the ways of HPLC systems cleanup are in the focus of this topic.

 

 

Dr. Laura Fernández Llano,
Product Manager

Combining Spectroscopy & Electrochemistry produces powerful results

Tuesday, September 4 th, 2019

 


Ing. Rainer Rozenich
Separations – Business Development Manager
Eastern European Region

“Analytical Method Life Cycle Management“
 
During this presentation you will learn about the concept of analytical method life cycle management based on a stimuli article for the U.S. Pharmacopeia.
The proposed new chapter “The Analytical Procedure Lifecycle ⟨1220⟩” explains how the implementation of a Quality by Design approach in method development ultimately leads to a better understanding of your test methods. You will know how to define the analytical target profile –the starting point in method development, and how the new concept will add flexibility to the method for future upcoming changes. Such changes could be of a major or minor classification. The supposed chapter 1220 also addresses how to cope with them in a regulated environment.

https://www.waters.com/waters/eventInstance.htm?eiid=135026614

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Will be announced soon